Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice
WY Chen, CJ Chen, CH Liu, FC Mao - Biochemical and biophysical …, 2010 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with insulin
resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role
in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this
study, we report that chromium supplementation has a beneficial effect against NAFLD. We
found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-
fat diet for 8weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic …
resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role
in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this
study, we report that chromium supplementation has a beneficial effect against NAFLD. We
found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-
fat diet for 8weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic …
Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HLJ mice.
CWY Chen WenYing, CCJ Chen ChunJung… - 2010 - cabidigitallibrary.org
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with insulin
resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role
in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this
study, we report that chromium supplementation has a beneficial effect against NAFLD. We
found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-
fat diet for 8 weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic …
resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role
in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this
study, we report that chromium supplementation has a beneficial effect against NAFLD. We
found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-
fat diet for 8 weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic …
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